Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

Immunoglobulins M (IgMs) are gaining increasing attention as biopharmaceuticals since their multivalent mode of binding can give rise to high avidity. Furthermore, IgMs are potent activators of the complement system. However, they are frequently difficult to express recombinantly and can suffer from...

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Detalles Bibliográficos
Autores principales: Chromikova, Veronika, Mader, Alexander, Hofbauer, Stefan, Göbl, Christoph, Madl, Tobias, Gach, Johannes S., Bauernfried, Stefan, Furtmüller, Paul G., Forthal, Donald N., Mach, Lukas, Obinger, Christian, Kunert, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582045/
https://www.ncbi.nlm.nih.gov/pubmed/25748881
http://dx.doi.org/10.1016/j.bbapap.2015.02.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582045/
https://www.ncbi.nlm.nih.gov/pubmed/25748881
http://dx.doi.org/10.1016/j.bbapap.2015.02.018

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