Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold

Protein A chromatography is a near-ubiquitous method of mAb capture in bioprocesses. The use of low pH buffer for elution from protein A is known to contribute to product aggregation. Yet, a more limited set of evidence suggests that low pH may not be the sole cause of aggregation in protein A chrom...

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Detalles Bibliográficos
Autores principales: Mazzer, Alice R., Perraud, Xavier, Halley, Jennifer, O’Hara, John, Bracewell, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582070/
https://www.ncbi.nlm.nih.gov/pubmed/26346187
http://dx.doi.org/10.1016/j.chroma.2015.08.068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582070/
https://www.ncbi.nlm.nih.gov/pubmed/26346187
http://dx.doi.org/10.1016/j.chroma.2015.08.068

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