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Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold
Protein A chromatography is a near-ubiquitous method of mAb capture in bioprocesses. The use of low pH buffer for elution from protein A is known to contribute to product aggregation. Yet, a more limited set of evidence suggests that low pH may not be the sole cause of aggregation in protein A chrom...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582070/ https://www.ncbi.nlm.nih.gov/pubmed/26346187 http://dx.doi.org/10.1016/j.chroma.2015.08.068 |