Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

Anti-angiogenic treatments against αvβ3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation o...

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Detalles Bibliográficos
Autores principales: Ellison, Tim S., Atkinson, Samuel J., Steri, Veronica, Kirkup, Benjamin M., Preedy, Michael E. J., Johnson, Robert T., Ruhrberg, Christiana, Edwards, Dylan R., Schneider, Jochen G., Weilbaecher, Katherine, Robinson, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582102/
https://www.ncbi.nlm.nih.gov/pubmed/26159543
http://dx.doi.org/10.1242/dmm.019927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582102/
https://www.ncbi.nlm.nih.gov/pubmed/26159543
http://dx.doi.org/10.1242/dmm.019927

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