The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection

TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hit mouse model of murine γ-herpesvirus 68 (MHV-68) in...

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Detalles Bibliográficos
Autores principales: Smoktunowicz, Natalia, Alexander, Robert E., Franklin, Linda, Williams, Andrew E., Holman, Beverley, Mercer, Paul F., Jarai, Gabor, Scotton, Chris J., Chambers, Rachel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582104/
https://www.ncbi.nlm.nih.gov/pubmed/26138704
http://dx.doi.org/10.1242/dmm.019984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582104/
https://www.ncbi.nlm.nih.gov/pubmed/26138704
http://dx.doi.org/10.1242/dmm.019984

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