Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils

Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity. Amyloid but not soluble forms of these peptides enhance HIV infection. Thus, agents that remodel these amyloi...

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Detalles Bibliográficos
Autores principales: Castellano, Laura M., Hammond, Rebecca M., Holmes, Veronica M., Weissman, Drew, Shorter, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582112/
https://www.ncbi.nlm.nih.gov/pubmed/26319581
http://dx.doi.org/10.1242/bio.010215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582112/
https://www.ncbi.nlm.nih.gov/pubmed/26319581
http://dx.doi.org/10.1242/bio.010215

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