AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms

The role of AMP-activated protein kinase (AMPK) in pancreatic β-cell apoptosis is still controversial, and the reasons for the discrepancies have not been clarified. In the current study, we observed the effects of two well-known AMPK activators 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)...

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Detalles Bibliográficos
Autores principales: Dai, Yu-Lu, Huang, Su-Ling, Leng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582151/
https://www.ncbi.nlm.nih.gov/pubmed/26435693
http://dx.doi.org/10.7150/ijbs.12108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582151/
https://www.ncbi.nlm.nih.gov/pubmed/26435693
http://dx.doi.org/10.7150/ijbs.12108

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