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TRX-LOGOS - a graphical tool to demonstrate DNA information content dependent upon backbone dynamics in addition to base sequence

BACKGROUND: It is now widely-accepted that DNA sequences defining DNA-protein interactions functionally depend upon local biophysical features of DNA backbone that are important in defining sites of binding interaction in the genome (e.g. DNA shape, charge and intrinsic dynamics). However, these phy...

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Detalles Bibliográficos
Autores principales: Fortin, Connor H., Schulze, Katharina V., Babbitt, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583169/
https://www.ncbi.nlm.nih.gov/pubmed/26413153
http://dx.doi.org/10.1186/s13029-015-0040-8