Chemical selectivity of nucleobase adduction relative to in vivo mutation sites on exon 7 fragment of p53 tumor suppressor gene

Damage to p53 tumor suppressor gene is found in half of all human cancers. Databases integrating studies of large numbers of tumors and cancer cell cultures show that mutation sites of specific p53 codons are correlated with specific types of cancers. If the most frequently damaged p53 codons in viv...

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Detalles Bibliográficos
Autores principales: Malla, Spundana, Kadimisetty, Karteek, Fu, You-Jun, Choudhary, Dharamainder, Jansson, Ingela, Schenkman, John B., Rusling, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583204/
https://www.ncbi.nlm.nih.gov/pubmed/26417421
http://dx.doi.org/10.1039/c5sc01403d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583204/
https://www.ncbi.nlm.nih.gov/pubmed/26417421
http://dx.doi.org/10.1039/c5sc01403d

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