Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors

BACKGROUND/AIM: Acetaminophen (APAP) hepatotoxicity is related to the formation of N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified through conjugation with reduced glutathione (GSH). Ophthalmic acid (OA) is an analogue of GSH in which cysteine is replaced with 2-aminobutyrate. Metabolomic...

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Detalles Bibliográficos
Autores principales: Kaur, Gurnit, Leslie, Elaine M., Tillman, Holly, Lee, William M., Swanlund, Diane P., Karvellas, Constantine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583290/
https://www.ncbi.nlm.nih.gov/pubmed/26407170
http://dx.doi.org/10.1371/journal.pone.0139299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583290/
https://www.ncbi.nlm.nih.gov/pubmed/26407170
http://dx.doi.org/10.1371/journal.pone.0139299

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