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Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors

BACKGROUND/AIM: Acetaminophen (APAP) hepatotoxicity is related to the formation of N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified through conjugation with reduced glutathione (GSH). Ophthalmic acid (OA) is an analogue of GSH in which cysteine is replaced with 2-aminobutyrate. Metabolomic...

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Detalles Bibliográficos
Autores principales:	Kaur, Gurnit, Leslie, Elaine M., Tillman, Holly, Lee, William M., Swanlund, Diane P., Karvellas, Constantine J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583290/ https://www.ncbi.nlm.nih.gov/pubmed/26407170 http://dx.doi.org/10.1371/journal.pone.0139299

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