Targeted Knock-Down of miR21 Primary Transcripts Using snoMEN Vectors Induces Apoptosis in Human Cancer Cell Lines

We have previously reported an antisense technology, ‘snoMEN vectors’, for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use of snoMEN vectors to target the knock-down of...

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Detalles Bibliográficos
Autores principales: Ono, Motoharu, Yamada, Kayo, Avolio, Fabio, Afzal, Vackar, Bensaddek, Dalila, Lamond, Angus I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583369/
https://www.ncbi.nlm.nih.gov/pubmed/26405811
http://dx.doi.org/10.1371/journal.pone.0138668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583369/
https://www.ncbi.nlm.nih.gov/pubmed/26405811
http://dx.doi.org/10.1371/journal.pone.0138668

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