Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

The Plasmodium falciparum PfA-M1 and PfA-M17 metalloaminopeptidases are validated drug targets for the discovery of antimalarial agents. In order to identify dual inhibitors of both proteins, we developed a hierarchical virtual screening approach, followed by in vitro evaluation of the highest scori...

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Detalles Bibliográficos
Autores principales: Ruggeri, Chiara, Drinkwater, Nyssa, Sivaraman, Komagal Kannan, Bamert, Rebecca S., McGowan, Sheena, Paiardini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583420/
https://www.ncbi.nlm.nih.gov/pubmed/26406322
http://dx.doi.org/10.1371/journal.pone.0138957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583420/
https://www.ncbi.nlm.nih.gov/pubmed/26406322
http://dx.doi.org/10.1371/journal.pone.0138957

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