Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an...

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Detalles Bibliográficos
Autores principales: Chertow, Jessica H., Alkaitis, Matthew S., Nardone, Glenn, Ikeda, Allison K., Cunnington, Aubrey J., Okebe, Joseph, Ebonyi, Augustine O., Njie, Madi, Correa, Simon, Jayasooriya, Shamanthi, Casals-Pascual, Climent, Billker, Oliver, Conway, David J., Walther, Michael, Ackerman, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583463/
https://www.ncbi.nlm.nih.gov/pubmed/26407009
http://dx.doi.org/10.1371/journal.ppat.1005119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583463/
https://www.ncbi.nlm.nih.gov/pubmed/26407009
http://dx.doi.org/10.1371/journal.ppat.1005119

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