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Genome-wide mapping of hot spots of DNA double-strand breaks in human cells as a tool for epigenetic studies and cancer genomics

Hot spots of DNA double-strand breaks (DSBs) are associated with coordinated expression of genes in chromosomal domains (Tchurikov et al., 2011 [1]; 2013). These 50–150-kb DNA domains (denoted “forum domains”) can be visualized by separation of undigested chromosomal DNA in pulsed-field agarose gels...

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Detalles Bibliográficos
Autores principales: Tchurikov, N.A., Kretova, O.V., Fedoseeva, D.M., Chechetkin, V.R., Gorbacheva, M.A., Snezhkina, A.V., Alembekov, I.R., Kravatskaya, G.I., Kravatsky, Y.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583641/
https://www.ncbi.nlm.nih.gov/pubmed/26484232
http://dx.doi.org/10.1016/j.gdata.2015.05.018