Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing na...

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Detalles Bibliográficos
Autores principales: Sliepen, Kwinten, Ozorowski, Gabriel, Burger, Judith A., van Montfort, Thijs, Stunnenberg, Melissa, LaBranche, Celia, Montefiori, David C., Moore, John P., Ward, Andrew B., Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583754/
https://www.ncbi.nlm.nih.gov/pubmed/26410741
http://dx.doi.org/10.1186/s12977-015-0210-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583754/
https://www.ncbi.nlm.nih.gov/pubmed/26410741
http://dx.doi.org/10.1186/s12977-015-0210-4

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