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Impact of kinetic isotope effects in isotopic studies of metabolic systems

BACKGROUND: Isotope labeling experiments (ILEs) are increasingly used to investigate the functioning of metabolic systems. Some enzymes are subject to kinetic isotope effects (KIEs) which modulate reaction rates depending on the isotopic composition of their substrate(s). KIEs may therefore affect b...

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Detalles Bibliográficos
Autores principales: Millard, Pierre, Portais, Jean-Charles, Mendes, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583766/
https://www.ncbi.nlm.nih.gov/pubmed/26410690
http://dx.doi.org/10.1186/s12918-015-0213-8