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The Fine LINE: Methylation Drawing the Cancer Landscape

LINE-1 (L1) is the most abundant mammalian transposable element that comprises nearly 20% of the genome, and nearly half of the mammalian genome has stemmed from L1-mediated mobilization. Expression and retrotransposition of L1 are suppressed by complex mechanisms, where the key role belongs to DNA...

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Detalles Bibliográficos
Autores principales: Miousse, Isabelle R., Koturbash, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584040/
https://www.ncbi.nlm.nih.gov/pubmed/26448926
http://dx.doi.org/10.1155/2015/131547
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author Miousse, Isabelle R.
Koturbash, Igor
author_facet Miousse, Isabelle R.
Koturbash, Igor
author_sort Miousse, Isabelle R.
collection PubMed
description LINE-1 (L1) is the most abundant mammalian transposable element that comprises nearly 20% of the genome, and nearly half of the mammalian genome has stemmed from L1-mediated mobilization. Expression and retrotransposition of L1 are suppressed by complex mechanisms, where the key role belongs to DNA methylation. Alterations in L1 methylation may lead to aberrant expression of L1 and have been described in numerous diseases. Accumulating evidence clearly indicates that loss of global DNA methylation observed in cancer development and progression is tightly associated with hypomethylation of L1 elements. Significant progress achieved in the last several years suggests that such parameters as L1 methylation status can be potentially utilized as clinical biomarkers for determination of the disease stage and in predicting the disease-free survival in cancer patients. In this paper, we summarize the current knowledge on L1 methylation, with specific emphasis given to success and challenges on the way of introduction of L1 into clinical practice.
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spelling pubmed-45840402015-10-07 The Fine LINE: Methylation Drawing the Cancer Landscape Miousse, Isabelle R. Koturbash, Igor Biomed Res Int Review Article LINE-1 (L1) is the most abundant mammalian transposable element that comprises nearly 20% of the genome, and nearly half of the mammalian genome has stemmed from L1-mediated mobilization. Expression and retrotransposition of L1 are suppressed by complex mechanisms, where the key role belongs to DNA methylation. Alterations in L1 methylation may lead to aberrant expression of L1 and have been described in numerous diseases. Accumulating evidence clearly indicates that loss of global DNA methylation observed in cancer development and progression is tightly associated with hypomethylation of L1 elements. Significant progress achieved in the last several years suggests that such parameters as L1 methylation status can be potentially utilized as clinical biomarkers for determination of the disease stage and in predicting the disease-free survival in cancer patients. In this paper, we summarize the current knowledge on L1 methylation, with specific emphasis given to success and challenges on the way of introduction of L1 into clinical practice. Hindawi Publishing Corporation 2015 2015-09-13 /pmc/articles/PMC4584040/ /pubmed/26448926 http://dx.doi.org/10.1155/2015/131547 Text en Copyright © 2015 I. R. Miousse and I. Koturbash. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Miousse, Isabelle R.
Koturbash, Igor
The Fine LINE: Methylation Drawing the Cancer Landscape
title The Fine LINE: Methylation Drawing the Cancer Landscape
title_full The Fine LINE: Methylation Drawing the Cancer Landscape
title_fullStr The Fine LINE: Methylation Drawing the Cancer Landscape
title_full_unstemmed The Fine LINE: Methylation Drawing the Cancer Landscape
title_short The Fine LINE: Methylation Drawing the Cancer Landscape
title_sort fine line: methylation drawing the cancer landscape
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584040/
https://www.ncbi.nlm.nih.gov/pubmed/26448926
http://dx.doi.org/10.1155/2015/131547
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