Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease

Our evidence demonstrated that CKD upregulated the expression of myostatin, TNF-α, and p-IkBa and downregulated the phosphorylation of PI3K, Akt, and FoxO3a, which were also associated with protein degradation and muscle atrophy. The autophagosome formation and protein expression of autophagy-relate...

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Detalles Bibliográficos
Autores principales: Wang, Dong-Tao, Yang, Ya-Jun, Huang, Ren-Hua, Zhang, Zhi-Hua, Lin, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584061/
https://www.ncbi.nlm.nih.gov/pubmed/26448817
http://dx.doi.org/10.1155/2015/684965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584061/
https://www.ncbi.nlm.nih.gov/pubmed/26448817
http://dx.doi.org/10.1155/2015/684965

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