Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes

[Image: see text] Multipolar interactions involving fluorine and the protein backbone have been frequently observed in protein–ligand complexes. Such fluorine–backbone interactions may substantially contribute to the high affinity of small molecule inhibitors. Here we found that introduction of trif...

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Detalles Bibliográficos
Autores principales: Pollock, Jonathan, Borkin, Dmitry, Lund, George, Purohit, Trupta, Dyguda-Kazimierowicz, Edyta, Grembecka, Jolanta, Cierpicki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584387/
https://www.ncbi.nlm.nih.gov/pubmed/26288158
http://dx.doi.org/10.1021/acs.jmedchem.5b00975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584387/
https://www.ncbi.nlm.nih.gov/pubmed/26288158
http://dx.doi.org/10.1021/acs.jmedchem.5b00975

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