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Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes
[Image: see text] Multipolar interactions involving fluorine and the protein backbone have been frequently observed in protein–ligand complexes. Such fluorine–backbone interactions may substantially contribute to the high affinity of small molecule inhibitors. Here we found that introduction of trif...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584387/ https://www.ncbi.nlm.nih.gov/pubmed/26288158 http://dx.doi.org/10.1021/acs.jmedchem.5b00975 |