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The evolutionary origin of the need to sleep: an inevitable consequence of synaptic neurotransmission?
It is proposed that the evolutionary origin of the need to sleep is the removal of neurotransmitters (NTs) that escape reuptake and accumulate in brain interstitial fluid (ISF). Recent work suggests that the activity of ionotropic postsynaptic receptors, rapidly initiated by binding of NTs to extrac...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585021/ https://www.ncbi.nlm.nih.gov/pubmed/26441631 http://dx.doi.org/10.3389/fnsyn.2015.00015 |