Assessing the synergy between cholinomimetics and memantine as augmentation therapy in cognitive impairment in schizophrenia. A virtual human patient trial using quantitative systems pharmacology

While many drug discovery research programs aim to develop highly selective clinical candidates, their clinical success is limited because of the complex non-linear interactions of human brain neuronal circuits. Therefore, a rational approach for identifying appropriate synergistic multipharmacology...

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Detalles Bibliográficos
Autores principales: Geerts, Hugo, Roberts, Patrick, Spiros, Athan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585031/
https://www.ncbi.nlm.nih.gov/pubmed/26441655
http://dx.doi.org/10.3389/fphar.2015.00198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585031/
https://www.ncbi.nlm.nih.gov/pubmed/26441655
http://dx.doi.org/10.3389/fphar.2015.00198

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