Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys

Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. I...

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Detalles Bibliográficos
Autores principales: Saletti, Patricia G., Maior, Rafael S., Hori, Etsuro, Nishijo, Hisao, Tomaz, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585034/
https://www.ncbi.nlm.nih.gov/pubmed/26441660
http://dx.doi.org/10.3389/fphar.2015.00204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585034/
https://www.ncbi.nlm.nih.gov/pubmed/26441660
http://dx.doi.org/10.3389/fphar.2015.00204

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