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Insights to ligand binding to the monoamine transporters—from homology modeling to LeuBAT and dDAT

Understanding of drug binding to the human biogenic amine transporters (BATs) is essential to explain the mechanism of action of these pharmaceuticals but more importantly to be able to develop new and improved compounds to be used in the treatment of depression or drug addiction. Until recently no...

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Detalles Bibliográficos
Autores principales: Koldsø, Heidi, Grouleff, Julie, Schiøtt, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585151/
https://www.ncbi.nlm.nih.gov/pubmed/26441663
http://dx.doi.org/10.3389/fphar.2015.00208