A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles

Mathematical modeling of excitation-contraction coupling (ECC) in ventricular cardiac myocytes is a multiscale problem, and it is therefore difficult to develop spatially detailed simulation tools. ECC involves gradients on the length scale of 100 nm in dyadic spaces and concentration profiles along...

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Detalles Bibliográficos
Autores principales: Vierheller, Janine, Neubert, Wilhelm, Falcke, Martin, Gilbert, Stephen H., Chamakuri, Nagaiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Physics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585174/
https://www.ncbi.nlm.nih.gov/pubmed/26441674
http://dx.doi.org/10.3389/fphys.2015.00255

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