Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway

The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase. For this reason, ligand-membrane interactions are as important determinants of inhibitor properties,...

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Detalles Bibliográficos
Autores principales: Lazar, Alexandra, Lenkey, Nora, Pesti, Krisztina, Fodor, Laszlo, Mike, Arpad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585259/
https://www.ncbi.nlm.nih.gov/pubmed/26441665
http://dx.doi.org/10.3389/fphar.2015.00210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585259/
https://www.ncbi.nlm.nih.gov/pubmed/26441665
http://dx.doi.org/10.3389/fphar.2015.00210

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