Fgf8-Deficient Mice Compensate for Reduced GnRH Neuronal Population and Exhibit Normal Testicular Function

Gonadotropin-releasing hormone (GnRH) is critical for the onset and maintenance of reproduction in vertebrates. The development of GnRH neurons is highly dependent on fibroblast growth factor (Fgf) signaling. Mice with a hypomorphic Fgf8 allele (Fgf8 Het) exhibited a ~50% reduction in GnRH neuron nu...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Johnson, Joshua I., Tsai, Pei-San
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585285/
https://www.ncbi.nlm.nih.gov/pubmed/26441841
http://dx.doi.org/10.3389/fendo.2015.00151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585285/
https://www.ncbi.nlm.nih.gov/pubmed/26441841
http://dx.doi.org/10.3389/fendo.2015.00151

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