Sensitive western blotting for detection of endogenous Ser129-phosphorylated α-synuclein in intracellular and extracellular spaces

α-Synuclein deposited in Lewy bodies, a pathological hallmark of Parkinson’s disease (PD), is highly phosphorylated at serine 129 (Ser129). In contrast, there is very little Ser129-phosphorylated α-synuclein in the normal brains. This difference suggests that Ser129-phosphorylation is involved in ne...

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Detalles Bibliográficos
Autores principales: Sasaki, Asuka, Arawaka, Shigeki, Sato, Hiroyasu, Kato, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585644/
https://www.ncbi.nlm.nih.gov/pubmed/26381815
http://dx.doi.org/10.1038/srep14211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585644/
https://www.ncbi.nlm.nih.gov/pubmed/26381815
http://dx.doi.org/10.1038/srep14211

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