Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis

Statin therapy is known to increase blood glucose levels in humans. Statins utilize pregnane X receptor (PXR) and serum/glucocorticoid regulated kinase 2 (SGK2) to activate phosphoenolpyruvate carboxykinase 1 (PEPCK1) and glucose-6-phosphatase (G6Pase) genes, thereby increasing glucose production in...

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Detalles Bibliográficos
Autores principales: Gotoh, Saki, Negishi, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585725/
https://www.ncbi.nlm.nih.gov/pubmed/26392083
http://dx.doi.org/10.1038/srep14076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585725/
https://www.ncbi.nlm.nih.gov/pubmed/26392083
http://dx.doi.org/10.1038/srep14076

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