Introduction of Methyl Groups at C2 and C6 Positions Enhances the Antiangiogenesis Activity of Curcumin

Curcumin has diverse biological activities, but is known to undergo rapid metabolism via reduction of vinylic double bonds and phase II conjugation. To prevent reductive metabolism of curcumin, we introduced a methyl group at both C2 and C6 positions (compound 1) or at the C2 position (compound 2) o...

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Detalles Bibliográficos
Autores principales: Koo, Hyun-Jung, Shin, Sarah, Choi, Joon Young, Lee, Kyung-Han, Kim, Byung-Tae, Choe, Yearn Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585748/
https://www.ncbi.nlm.nih.gov/pubmed/26391485
http://dx.doi.org/10.1038/srep14205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585748/
https://www.ncbi.nlm.nih.gov/pubmed/26391485
http://dx.doi.org/10.1038/srep14205

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