Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

The recent identification of three broadly neutralizing antibodies (bnAbs) against gp120–gp41 interface epitopes has expanded the targetable surface on the HIV-1 envelope glycoprotein (Env) trimer. By using biochemical, biophysical and computational methods, we map the previously unknown trimer epit...

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Detalles Bibliográficos
Autores principales: Lee, Jeong Hyun, Leaman, Daniel P., Kim, Arthur S., Torrents de la Peña, Alba, Sliepen, Kwinten, Yasmeen, Anila, Derking, Ronald, Ramos, Alejandra, de Taeye, Steven W., Ozorowski, Gabriel, Klein, Florian, Burton, Dennis R., Nussenzweig, Michel C., Poignard, Pascal, Moore, John P., Klasse, Per Johan, Sanders, Rogier W., Zwick, Michael B., Wilson, Ian A., Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586043/
https://www.ncbi.nlm.nih.gov/pubmed/26404402
http://dx.doi.org/10.1038/ncomms9167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586043/
https://www.ncbi.nlm.nih.gov/pubmed/26404402
http://dx.doi.org/10.1038/ncomms9167

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