Elucidation of Enzymatic Mechanism of Phenazine Biosynthetic Protein PhzF Using QM/MM and MD Simulations

The phenazine biosynthetic pathway is of considerable importance for the pharmaceutical industry. The pathway produces two products: phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid. PhzF is an isomerase that catalyzes trans-2,3-dihydro-3-hydroxyanthranilic acid isomerization and play...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Fei, Zhao, Yi-Lei, Wang, Xiaolei, Hu, Hongbo, Peng, Huasong, Wang, Wei, Wang, Jing-Fang, Zhang, Xuehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586147/
https://www.ncbi.nlm.nih.gov/pubmed/26414009
http://dx.doi.org/10.1371/journal.pone.0139081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586147/
https://www.ncbi.nlm.nih.gov/pubmed/26414009
http://dx.doi.org/10.1371/journal.pone.0139081

Ejemplares similares