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Elucidation of Enzymatic Mechanism of Phenazine Biosynthetic Protein PhzF Using QM/MM and MD Simulations

The phenazine biosynthetic pathway is of considerable importance for the pharmaceutical industry. The pathway produces two products: phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid. PhzF is an isomerase that catalyzes trans-2,3-dihydro-3-hydroxyanthranilic acid isomerization and play...

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Detalles Bibliográficos
Autores principales:	Liu, Fei, Zhao, Yi-Lei, Wang, Xiaolei, Hu, Hongbo, Peng, Huasong, Wang, Wei, Wang, Jing-Fang, Zhang, Xuehong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586147/ https://www.ncbi.nlm.nih.gov/pubmed/26414009 http://dx.doi.org/10.1371/journal.pone.0139081

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