Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren

We report that the DNA methylation profile of a child’s neonatal whole blood can be significantly influenced by his or her mother’s neonatal blood lead levels (BLL). We recruited 35 mother-infant pairs in Detroit and measured the whole blood lead (Pb) levels and DNA methylation levels at over 450,00...

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Detalles Bibliográficos
Autores principales: Sen, Arko, Heredia, Nicole, Senut, Marie-Claude, Land, Susan, Hollocher, Kurt, Lu, Xiangyi, Dereski, Mary O., Ruden, Douglas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586440/
https://www.ncbi.nlm.nih.gov/pubmed/26417717
http://dx.doi.org/10.1038/srep14466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586440/
https://www.ncbi.nlm.nih.gov/pubmed/26417717
http://dx.doi.org/10.1038/srep14466

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