Cargando…

Reconciling depressed Ca(2+) sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes

Abnormalities in cardiomyocyte Ca(2+) handling contribute to impaired contractile function in heart failure (HF). Experiments on single ryanodine receptors (RyRs) incorporated into lipid bilayers have indicated that RyRs from failing hearts are more active than those from healthy hearts. Here, we an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruiz-Hurtado, Gema, Li, Linwei, Fernández-Velasco, María, Rueda, Angélica, Lefebvre, Florence, Wang, Yueyi, Mateo, Philippe, Cassan, Cécile, Gellen, Barnabas, Benitah, Jean Pierre, Gómez, Ana María
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586588/ https://www.ncbi.nlm.nih.gov/pubmed/26371209 http://dx.doi.org/10.1085/jgp.201511366

Ejemplares similares

RyR2 and Calcium Release in Heart Failure
por: Benitah, Jean-Pierre, et al.
Publicado: (2021)

Calcium Activation of Ryanodine Receptor Channels—Reconciling RyR Gating Models with Tetrameric Channel Structure
por: Zahradník, Ivan, et al.
Publicado: (2005)

Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model
por: Lu, Luyao, et al.
Publicado: (2012)

Structure of RyR1 in native membranes
por: Chen, Wenbo, et al.
Publicado: (2020)

Identification of RyR2-PBmice and the effects of transposon insertional mutagenesis of the RyR2 gene on cardiac function in mice
por: Wang, Qianqian, et al.
Publicado: (2019)

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform
por: Venturi, Elisa, et al.
Publicado: (2018)

On the Adjacency Matrix of RyR2 Cluster Structures
por: Walker, Mark A., et al.
Publicado: (2015)

Review of RyR1 pathway and associated pathomechanisms
por: Witherspoon, Jessica W., et al.
Publicado: (2016)

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca(2+) Release Patterns in Cardiomyocytes
por: Rajagopal, Vijay, et al.
Publicado: (2015)

RyRCa(2+) Leak Limits Cardiac Ca(2+) Window Current Overcoming the Tonic Effect of Calmodulin in Mice
por: Fernández-Velasco, María, et al.
Publicado: (2011)

Calcium Signaling Consequences of RyR2-S4938F Mutation Expressed in Human iPSC-Derived Cardiomyocytes
por: Toth, Noemi, et al.
Publicado: (2023)

Functional Characterization of a Central Core Disease RyR1 Mutation (p.Y4864H) Associated with Quantitative Defect in RyR1 Protein
por: Cacheux, Marine, et al.
Publicado: (2015)

The Arianna thread: the matching of S-100 family with the RyR’s muscle receptor
por: Fulle, Stefania, et al.
Publicado: (2020)

Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease
por: Fowler, Ewan Douglas, et al.
Publicado: (2022)

How does flecainide impact RyR2 channel function?
por: Salvage, Samantha C., et al.
Publicado: (2022)

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool
por: Wegener, Jörg W., et al.
Publicado: (2021)

Regulation of Ca(2+) Sparks by Ca(2+) and Mg(2+) in Mammalian and Amphibian Muscle. An RyR Isoform-specific Role in Excitation–Contraction Coupling?
por: Zhou, Jingsong, et al.
Publicado: (2004)

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating
por: Samsó, Montserrat, et al.
Publicado: (2009)

Voltage-Dependent Modulation of Cardiac Ryanodine Receptors (RyR2) by Protamine
por: Diaz-Sylvester, Paula L., et al.
Publicado: (2009)

Zinc controls RyR2 activity during excitation-contraction coupling
por: Stewart, Alan J, et al.
Publicado: (2015)

RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias
por: Galati, Francesca, et al.
Publicado: (2016)

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution
por: Yan, Zhen, et al.
Publicado: (2014)

Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain
por: Polster, Alexander, et al.
Publicado: (2018)

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
por: Roy Chowdhury, Anindya, et al.
Publicado: (2020)

Synergistic FRET assays for drug discovery targeting RyR2 channels
por: Rebbeck, RobynT., et al.
Publicado: (2022)

The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2
por: Hu, Jianshu, et al.
Publicado: (2023)

Regulation of ryanodine receptor RyR2 by protein-protein interactions: prediction of a PKA binding site on the N-terminal domain of RyR2 and its relation to disease causing mutations
por: Walpoth, Belinda Nazan, et al.
Publicado: (2015)

Abnormal Ca(2+) Spark/STOC Coupling in Cerebral Artery Smooth Muscle Cells of Obese Type 2 Diabetic Mice
por: Rueda, Angélica, et al.
Publicado: (2013)

Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin
por: Knoblauch, Mark, et al.
Publicado: (2013)

Identification of ATP-Binding Regions in the RyR1 Ca(2+) Release Channel
por: Popova, Olga B., et al.
Publicado: (2012)

Both RyRs and TPCs are required for NAADP-induced intracellular Ca(2+) release
por: Gerasimenko, Julia V., et al.
Publicado: (2015)

R4496C RyR2 mutation impairs atrial and ventricular contractility
por: Ferrantini, Cecilia, et al.
Publicado: (2016)

iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated dystrophin
por: Nogami, Ken’ichiro, et al.
Publicado: (2020)

Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS
por: Hamilton, Shanna, et al.
Publicado: (2020)

In vivo RyR1 reduction in muscle triggers a core-like myopathy
por: Pelletier, Laurent, et al.
Publicado: (2020)

Molecular Changes in the Cardiac RyR2 With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
por: Dulhunty, Angela F.
Publicado: (2022)

Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
por: Okolo, Chidinma A, et al.
Publicado: (2023)

Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation
por: More, Jamileth, et al.
Publicado: (2018)

Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias
por: Borko, Ľubomír, et al.
Publicado: (2014)

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
por: Bai, Xiao-Chen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l7mvpkkoi1fro0v2q3t2dno2qa