CYP450 Enzyme-Mediated Metabolism of TCAS and Its Inhibitory and Induced Effects on Metabolized Enzymes in Vitro

In this study, we investigated the enzymes catalyzing the phaseⅠmetabolism of thiacalixarene (TCAS) based on in vitro system including cDNA-expressed P450 enzymes, human liver microsomes plus inhibitors and monoclonal antibodies. In addition, the inhibitory potential of TCAS on major CYP450 drug met...

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Detalles Bibliográficos
Autores principales: Shen, Guolin, Wang, Cheng, Zhou, Lili, Li, Lei, Chen, Huiming, Yu, Wenlian, Li, Haishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586642/
https://www.ncbi.nlm.nih.gov/pubmed/26404338
http://dx.doi.org/10.3390/ijerph120910783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586642/
https://www.ncbi.nlm.nih.gov/pubmed/26404338
http://dx.doi.org/10.3390/ijerph120910783

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