Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures

The role of microglia in amyloid-β (Aβ) deposition is controversial. In the present study, an organotypic hippocampal slice culture (OHSC) system with an in vivo-like microglial-neuronal environment was used to investigate the potential contribution of microglia to Aβ plaque formation. We found that...

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Detalles Bibliográficos
Autores principales: Hellwig, Sabine, Masuch, Annette, Nestel, Sigrun, Katzmarski, Natalie, Meyer-Luehmann, Melanie, Biber, Knut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586757/
https://www.ncbi.nlm.nih.gov/pubmed/26416689
http://dx.doi.org/10.1038/srep14624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586757/
https://www.ncbi.nlm.nih.gov/pubmed/26416689
http://dx.doi.org/10.1038/srep14624

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