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Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis
The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586781/ https://www.ncbi.nlm.nih.gov/pubmed/26258793 http://dx.doi.org/10.3390/cancers7030848 |