The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells

Colorectal cancer is a major global health problem resulting in over 600,000 deaths world-wide every year with the majority of these due to metastatic disease. Wnt signalling, and more specifically β-catenin-related transcription, has been shown to drive both tumorigenesis and the metastatic process...

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Detalles Bibliográficos
Autores principales: Qualtrough, David, Rees, Phil, Speight, Beverley, Williams, Ann C., Paraskeva, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586800/
https://www.ncbi.nlm.nih.gov/pubmed/26393651
http://dx.doi.org/10.3390/cancers7030867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586800/
https://www.ncbi.nlm.nih.gov/pubmed/26393651
http://dx.doi.org/10.3390/cancers7030867

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