Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome

Site-specific recombinases (SSRs) are valuable tools for genetic engineering due to their ability to manipulate DNA in a highly specific manner. Engineered zinc-finger and TAL effector recombinases, in particular, are two classes of SSRs composed of custom-designed DNA-binding domains fused to a cat...

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Detalles Bibliográficos
Autores principales: Wallen, Mark C., Gaj, Thomas, Barbas, Carlos F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587366/
https://www.ncbi.nlm.nih.gov/pubmed/26414179
http://dx.doi.org/10.1371/journal.pone.0139123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587366/
https://www.ncbi.nlm.nih.gov/pubmed/26414179
http://dx.doi.org/10.1371/journal.pone.0139123

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