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Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome
Site-specific recombinases (SSRs) are valuable tools for genetic engineering due to their ability to manipulate DNA in a highly specific manner. Engineered zinc-finger and TAL effector recombinases, in particular, are two classes of SSRs composed of custom-designed DNA-binding domains fused to a cat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587366/ https://www.ncbi.nlm.nih.gov/pubmed/26414179 http://dx.doi.org/10.1371/journal.pone.0139123 |