Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic stability and cancer development. Imbalanced dNTP pools can lead to enhanced mutagenesis and cell proliferation resulting in cancer development. Therapeutic agents that target dNTP synthesis and metabolism ar...

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Detalles Bibliográficos
Autores principales: Kohnken, Rebecca, Kodigepalli, Karthik M., Wu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587406/
https://www.ncbi.nlm.nih.gov/pubmed/26416562
http://dx.doi.org/10.1186/s12943-015-0446-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587406/
https://www.ncbi.nlm.nih.gov/pubmed/26416562
http://dx.doi.org/10.1186/s12943-015-0446-6

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