Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Genomic analyses promise to improve tumor characterization in order to optimize personalized treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of 243 liver tumors revealed mutational signatures associated with specific risk factors, mainly combined alcohol/tobacco...

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Detalles Bibliográficos
Autores principales: Schulze, Kornelius, Imbeaud, Sandrine, Letouzé, Eric, Alexandrov, Ludmil B, Calderaro, Julien, Rebouissou, Sandra, Couchy, Gabrielle, Meiller, Clément, Shinde, Jayendra, Soysouvanh, Frederic, Calatayud, Anna-Line, Pinyol, Roser, Pelletier, Laura, Balabaud, Charles, Laurent, Alexis, Blanc, Jean-Frederic, Mazzaferro, Vincenzo, Calvo, Fabien, Villanueva, Augusto, Nault, Jean-Charles, Bioulac-Sage, Paulette, Stratton, Michael R, Llovet, Josep M, Zucman-Rossi, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587544/
https://www.ncbi.nlm.nih.gov/pubmed/25822088
http://dx.doi.org/10.1038/ng.3252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587544/
https://www.ncbi.nlm.nih.gov/pubmed/25822088
http://dx.doi.org/10.1038/ng.3252

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