Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

Gaucher disease is characterized by lysosomal accumulation of glucosylceramide due to deficient activity of lysosomal glucocerebrosidase (GBA). In cells, glucosylceramide is also degraded outside lysosomes by the enzyme glucosylceramidase 2 (GBA2) of which inherited deficiency is associated with ata...

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Detalles Bibliográficos
Autores principales: Herrera Moro Chao, Daniela, Kallemeijn, Wouter W., Marques, Andre R. A., Orre, Marie, Ottenhoff, Roelof, van Roomen, Cindy, Foppen, Ewout, Renner, Maria C., Moeton, Martina, van Eijk, Marco, Boot, Rolf G., Kamphuis, Willem, Hol, Elly M., Aten, Jan, Overkleeft, Hermen S., Kalsbeek, Andries, Aerts, Johannes M. F. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587854/
https://www.ncbi.nlm.nih.gov/pubmed/26418157
http://dx.doi.org/10.1371/journal.pone.0138107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587854/
https://www.ncbi.nlm.nih.gov/pubmed/26418157
http://dx.doi.org/10.1371/journal.pone.0138107

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