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Differential replicative ability of clinical dengue virus isolates in an immunocompetent C57BL/6 mouse model

BACKGROUND: Several experimental animal models have been used to study the pathogenesis of dengue disease; however, most of the studies used laboratory-adapted viruses, which lack the virulence of viruses circulating in humans. The aim of this study was to analyze the ability of clinical Dengue viru...

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Detalles Bibliográficos
Autores principales: Barros, Veridiana Ester, dos Santos-Junior, Nilton Nascimento, Amarilla, Alberto Anastacio, Soares, Adriana Moreira, Lourencini, Rafael, Trabuco, Amanda Cristina, Aquino, Victor Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587874/
https://www.ncbi.nlm.nih.gov/pubmed/26415508
http://dx.doi.org/10.1186/s12866-015-0520-7