Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays

Cellular NAD(P)H-dependent oxidoreductase activity with artificial dyes (NAD(P)H-OR) is an indicator of viability, as the cellular redox state is important for biosynthesis and antioxidant defense. However, high NAD(P)H due to impaired mitochondrial oxidation, known as reductive stress, should incre...

Descripción completa

Detalles Bibliográficos
Autores principales: Aleshin, Vasily A., Artiukhov, Artem V., Oppermann, Henry, Kazantsev, Alexey V., Lukashev, Nikolay V., Bunik, Victoria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588044/
https://www.ncbi.nlm.nih.gov/pubmed/26308058
http://dx.doi.org/10.3390/cells4030427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588044/
https://www.ncbi.nlm.nih.gov/pubmed/26308058
http://dx.doi.org/10.3390/cells4030427

Ejemplares similares