Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generall...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588186/ https://www.ncbi.nlm.nih.gov/pubmed/26402689 http://dx.doi.org/10.3390/ph8030637 |
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author | Thomford, Nicholas E. Dzobo, Kevin Chopera, Denis Wonkam, Ambroise Skelton, Michelle Blackhurst, Dee Chirikure, Shadreck Dandara, Collet |
author_facet | Thomford, Nicholas E. Dzobo, Kevin Chopera, Denis Wonkam, Ambroise Skelton, Michelle Blackhurst, Dee Chirikure, Shadreck Dandara, Collet |
author_sort | Thomford, Nicholas E. |
collection | PubMed |
description | The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, the overlap between conventional medicine and herbal medicine is a reality among countries in health systems transition. Patients often simultaneously seek treatment from both conventional and traditional health systems for the same condition. Commonly encountered conditions/diseases include malaria, HIV/AIDS, hypertension, tuberculosis, and bleeding disorders. It is therefore imperative to understand the modes of interaction between different drugs from conventional and traditional health care systems when used in treatment combinations. Both conventional and traditional drug entities are metabolized by the same enzyme systems in the human body, resulting in both pharmacokinetics and pharmacodynamics interactions, whose properties remain unknown/unquantified. Thus, it is important that profiles of interaction between different herbal and conventional medicines be evaluated. This review evaluates herbal and conventional drugs in a few African countries and their potential interaction at the pharmacogenomics level. |
format | Online Article Text |
id | pubmed-4588186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45881862015-10-08 Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition Thomford, Nicholas E. Dzobo, Kevin Chopera, Denis Wonkam, Ambroise Skelton, Michelle Blackhurst, Dee Chirikure, Shadreck Dandara, Collet Pharmaceuticals (Basel) Article The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, the overlap between conventional medicine and herbal medicine is a reality among countries in health systems transition. Patients often simultaneously seek treatment from both conventional and traditional health systems for the same condition. Commonly encountered conditions/diseases include malaria, HIV/AIDS, hypertension, tuberculosis, and bleeding disorders. It is therefore imperative to understand the modes of interaction between different drugs from conventional and traditional health care systems when used in treatment combinations. Both conventional and traditional drug entities are metabolized by the same enzyme systems in the human body, resulting in both pharmacokinetics and pharmacodynamics interactions, whose properties remain unknown/unquantified. Thus, it is important that profiles of interaction between different herbal and conventional medicines be evaluated. This review evaluates herbal and conventional drugs in a few African countries and their potential interaction at the pharmacogenomics level. MDPI 2015-09-21 /pmc/articles/PMC4588186/ /pubmed/26402689 http://dx.doi.org/10.3390/ph8030637 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Thomford, Nicholas E. Dzobo, Kevin Chopera, Denis Wonkam, Ambroise Skelton, Michelle Blackhurst, Dee Chirikure, Shadreck Dandara, Collet Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition |
title | Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition |
title_full | Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition |
title_fullStr | Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition |
title_full_unstemmed | Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition |
title_short | Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition |
title_sort | pharmacogenomics implications of using herbal medicinal plants on african populations in health transition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588186/ https://www.ncbi.nlm.nih.gov/pubmed/26402689 http://dx.doi.org/10.3390/ph8030637 |
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