Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition

The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generall...

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Autores principales: Thomford, Nicholas E., Dzobo, Kevin, Chopera, Denis, Wonkam, Ambroise, Skelton, Michelle, Blackhurst, Dee, Chirikure, Shadreck, Dandara, Collet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588186/
https://www.ncbi.nlm.nih.gov/pubmed/26402689
http://dx.doi.org/10.3390/ph8030637
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author Thomford, Nicholas E.
Dzobo, Kevin
Chopera, Denis
Wonkam, Ambroise
Skelton, Michelle
Blackhurst, Dee
Chirikure, Shadreck
Dandara, Collet
author_facet Thomford, Nicholas E.
Dzobo, Kevin
Chopera, Denis
Wonkam, Ambroise
Skelton, Michelle
Blackhurst, Dee
Chirikure, Shadreck
Dandara, Collet
author_sort Thomford, Nicholas E.
collection PubMed
description The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, the overlap between conventional medicine and herbal medicine is a reality among countries in health systems transition. Patients often simultaneously seek treatment from both conventional and traditional health systems for the same condition. Commonly encountered conditions/diseases include malaria, HIV/AIDS, hypertension, tuberculosis, and bleeding disorders. It is therefore imperative to understand the modes of interaction between different drugs from conventional and traditional health care systems when used in treatment combinations. Both conventional and traditional drug entities are metabolized by the same enzyme systems in the human body, resulting in both pharmacokinetics and pharmacodynamics interactions, whose properties remain unknown/unquantified. Thus, it is important that profiles of interaction between different herbal and conventional medicines be evaluated. This review evaluates herbal and conventional drugs in a few African countries and their potential interaction at the pharmacogenomics level.
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spelling pubmed-45881862015-10-08 Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition Thomford, Nicholas E. Dzobo, Kevin Chopera, Denis Wonkam, Ambroise Skelton, Michelle Blackhurst, Dee Chirikure, Shadreck Dandara, Collet Pharmaceuticals (Basel) Article The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, the overlap between conventional medicine and herbal medicine is a reality among countries in health systems transition. Patients often simultaneously seek treatment from both conventional and traditional health systems for the same condition. Commonly encountered conditions/diseases include malaria, HIV/AIDS, hypertension, tuberculosis, and bleeding disorders. It is therefore imperative to understand the modes of interaction between different drugs from conventional and traditional health care systems when used in treatment combinations. Both conventional and traditional drug entities are metabolized by the same enzyme systems in the human body, resulting in both pharmacokinetics and pharmacodynamics interactions, whose properties remain unknown/unquantified. Thus, it is important that profiles of interaction between different herbal and conventional medicines be evaluated. This review evaluates herbal and conventional drugs in a few African countries and their potential interaction at the pharmacogenomics level. MDPI 2015-09-21 /pmc/articles/PMC4588186/ /pubmed/26402689 http://dx.doi.org/10.3390/ph8030637 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thomford, Nicholas E.
Dzobo, Kevin
Chopera, Denis
Wonkam, Ambroise
Skelton, Michelle
Blackhurst, Dee
Chirikure, Shadreck
Dandara, Collet
Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
title Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
title_full Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
title_fullStr Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
title_full_unstemmed Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
title_short Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
title_sort pharmacogenomics implications of using herbal medicinal plants on african populations in health transition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588186/
https://www.ncbi.nlm.nih.gov/pubmed/26402689
http://dx.doi.org/10.3390/ph8030637
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