Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity

Chemical modification of nucleosides in mRNA is an important technology to regulate the immunogenicity of mRNA. In this study, various previously reported mRNA formulations were evaluated by analyzing in vitro protein expression and immunogenicity in multiple cell lines. For the macrophage-derived c...

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Detalles Bibliográficos
Autores principales: Uchida, Satoshi, Kataoka, Kazunori, Itaka, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588190/
https://www.ncbi.nlm.nih.gov/pubmed/26213960
http://dx.doi.org/10.3390/pharmaceutics7030137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588190/
https://www.ncbi.nlm.nih.gov/pubmed/26213960
http://dx.doi.org/10.3390/pharmaceutics7030137

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