Cargando…

Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity

Chemical modification of nucleosides in mRNA is an important technology to regulate the immunogenicity of mRNA. In this study, various previously reported mRNA formulations were evaluated by analyzing in vitro protein expression and immunogenicity in multiple cell lines. For the macrophage-derived c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uchida, Satoshi, Kataoka, Kazunori, Itaka, Keiji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588190/ https://www.ncbi.nlm.nih.gov/pubmed/26213960 http://dx.doi.org/10.3390/pharmaceutics7030137

Ejemplares similares

mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy
por: Uchida, Satoshi, et al.
Publicado: (2020)

Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA
por: Crowley, Samuel T., et al.
Publicado: (2019)

Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor
por: Lin, Chin-Yu, et al.
Publicado: (2019)

Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases
por: Matsui, Akitsugu, et al.
Publicado: (2015)

Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids
por: Yanagihara, Kayoko, et al.
Publicado: (2018)

Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification
por: Vaidyanathan, Sriram, et al.
Publicado: (2018)

Administration of mRNA-Nanomedicine-Augmented Calvarial Defect Healing via Endochondral Ossification
por: Tsou, Hsi-Kai, et al.
Publicado: (2023)

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle
por: Uchida, Satoshi, et al.
Publicado: (2013)

Combined CatWalk Index: an improved method to measure mouse motor function using the automated gait analysis system
por: Crowley, Samuel T., et al.
Publicado: (2018)

Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment
por: Aini, Hailati, et al.
Publicado: (2016)

Efficient mRNA Delivery with Lyophilized Human Serum Albumin-Based Nanobubbles
por: Kida, Hiroshi, et al.
Publicado: (2023)

The Pivotal Role of Chemical Modifications in mRNA Therapeutics
por: Liu, Albert, et al.
Publicado: (2022)

Chemical Modifications of mRNA Ends for Therapeutic Applications
por: Warminski, Marcin, et al.
Publicado: (2023)

Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying
por: Okuda, Tomoyuki, et al.
Publicado: (2015)

mRNA knockdown by single strand RNA is improved by chemical modifications
por: Haringsma, Henry J., et al.
Publicado: (2012)

Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery
por: Du, Xuan, et al.
Publicado: (2023)

Maximizing mRNA vaccine production with Bayesian optimization
por: Rosa, Sara Sousa, et al.
Publicado: (2022)

Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA
por: van Dülmen, Melissa, et al.
Publicado: (2021)

Raman spectroscopic insight into osteoarthritic cartilage regeneration by mRNA therapeutics encoding cartilage-anabolic transcription factor Runx1
por: Pezzotti, Giuseppe, et al.
Publicado: (2022)

New mRNA modification?
por: Leslie, Mitch
Publicado: (2007)

Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist
por: Deng, Jia, et al.
Publicado: (2022)

RNA modification in mRNA cancer vaccines
por: Mei, Yingxue, et al.
Publicado: (2023)

Analysis of mRNA m(6)A modification and mRNA expression profiles in middle ear cholesteatoma
por: Xie, Shumin, et al.
Publicado: (2023)

mRNA modifications: Dynamic regulators of gene expression?
por: Hoernes, Thomas Philipp, et al.
Publicado: (2016)

Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety
por: Vlatkovic, Irena
Publicado: (2021)

Safety and immunogenicity of mRNA COVID‐19 vaccine in inpatients with muscular dystrophy
por: Saito, Tomoko, et al.
Publicado: (2022)

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
por: Jiang, Tingting, et al.
Publicado: (2020)

Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters
por: Collier, Ai-ris Y., et al.
Publicado: (2023)

Adenovirus vector and mRNA vaccines: Mechanisms regulating their immunogenicity
por: Provine, Nicholas M., et al.
Publicado: (2022)

Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters
por: Collier, Ai-ris Y., et al.
Publicado: (2022)

Construction and immunogenicity of an mRNA vaccine against chikungunya virus
por: Liu, Jingjing, et al.
Publicado: (2023)

Algorithm for optimized mRNA design improves stability and immunogenicity
por: Zhang, He, et al.
Publicado: (2023)

Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines
por: Lee, Jisun, et al.
Publicado: (2023)

PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration
por: Kurimoto, Shota, et al.
Publicado: (2019)

In search of the mRNA modification landscape in plants
por: Chmielowska-Bąk, Jagna, et al.
Publicado: (2019)

Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency
por: Kim, Sun Chang, et al.
Publicado: (2021)

Reduced immunogenicity of the mRNA vaccine BNT162b2 in patients with idiopathic pulmonary fibrosis
por: Karampitsakos, Theodoros, et al.
Publicado: (2022)

PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials
por: Yoshinaga, Naoto, et al.
Publicado: (2021)

Impaired CD4(+) T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination
por: Jo, Norihide, et al.
Publicado: (2023)

Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19
por: Lim, Wey Wen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eehaajg2nltt0ks60ri70v2n17